Aaron Wan-Bissaka, Jonny Evans and Victor Lindelof all looked to suffer knocks at Williams Brice Stadium in Columbia, South Carolina.
United were initially reluctant to disclose the severity of Yoro’s injury, according to a report, as they were worried it would harm their stance in negotiations with Bayern Munich over a deal for Matthijs de Ligt.
The Red Devils saw a double-bid for De Ligt and Morocco international Noussair Mazraoui recently rejected by the Bundesliga giants, though talks are thought to still be continuing.